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dc.contributor.author권영주-
dc.date.accessioned2017-08-29T04:05:38Z-
dc.date.available2017-08-29T04:05:38Z-
dc.date.issued2015-
dc.identifier.issn0968-0896-
dc.identifier.otherOAK-15036-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/230600-
dc.description.abstractAbstract A series of novel twenty-eight rigid 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines were synthesized and evaluated for their topoisomerase inhibitory activity as well as their cytotoxicity against several human cancer cell lines. Generally, hydroxylated compounds (16-18, 22-25, and 29-31) containing furyl or thienyl moiety at 4-position of central pyridine exhibited strong topoisomerase I and II inhibitory activity compared to positive control, camptothecin and etoposide, respectively, in low micromolar range. Structure-activity relationship study revealed that indenopyridine compounds with hydroxyl group at 2-phenyl ring in combination with furyl or thienyl moiety at 4-position are important for topoisomerase inhibition. Compounds (22-25) which contain hydroxyl group at meta position of the 2-phenyl ring at 2-position and furanyl or thienyl substitution at 4-position of indenopyridine, showed concrete correlations between topo I and II inhibitory activity, and cytotoxicity against evaluated human cancer cell lines. © 2015 Elsevier Ltd.-
dc.languageEnglish-
dc.publisherElsevier Ltd-
dc.subjectAnticancer agents-
dc.subjectCytotoxicity-
dc.subjectHydroxylated 2-phenyl-4-aryl-5Hindeno[1,2-b]pyridines-
dc.subjectTopoisomerase I and II inhibitor-
dc.titleSynthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines-
dc.typeArticle-
dc.relation.issue13-
dc.relation.volume23-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage3499-
dc.relation.lastpage3512-
dc.relation.journaltitleBioorganic and Medicinal Chemistry-
dc.identifier.doi10.1016/j.bmc.2015.04.031-
dc.identifier.wosidWOS:000355848900055-
dc.identifier.scopusid2-s2.0-84937409563-
dc.author.googleKadayat T.M.-
dc.author.googleSong C.-
dc.author.googleShin S.-
dc.author.googleMagar T.B.T.-
dc.author.googleBist G.-
dc.author.googleShrestha A.-
dc.author.googleThapa P.-
dc.author.googleNa Y.-
dc.author.googleKwon Y.-
dc.author.googleLee E.-S.-
dc.contributor.scopusid권영주(12446435600)-
dc.date.modifydate20180104081001-
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약학대학 > 약학과 > Journal papers
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