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약학대학
약학과
Journal papers
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Short-term treatment of daumone improves hepatic inflammation in aged mice
Title
Short-term treatment of daumone improves hepatic inflammation in aged mice
Authors
Park J.H.
;
Ha H.
Ewha Authors
하헌주
SCOPUS Author ID
하헌주
Issue Date
2015
Journal Title
Korean Journal of Physiology and Pharmacology
ISSN
1226-4512
Citation
Korean Journal of Physiology and Pharmacology vol. 19, no. 3, pp. 269 - 274
Keywords
Aging
;
Hep G2 cells
;
Inflammation
;
Liver
;
Pheromones
Publisher
Korean Physiological Soc. and Korean Soc. of Pharmacology
Indexed
SCIE; SCOPUS; KCI
Document Type
Article
Abstract
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NF-κB) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-κB signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases. Copyright © Korean J Physiol Pharmacol & MEDrang Inc.
DOI
10.4196/kjpp.2015.19.3.269
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