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Short-term treatment of daumone improves hepatic inflammation in aged mice

Title
Short-term treatment of daumone improves hepatic inflammation in aged mice
Authors
Park J.H.Ha H.
Ewha Authors
하헌주
SCOPUS Author ID
하헌주scopus
Issue Date
2015
Journal Title
Korean Journal of Physiology and Pharmacology
ISSN
1226-4512JCR Link
Citation
vol. 19, no. 3, pp. 269 - 274
Keywords
AgingHep G2 cellsInflammationLiverPheromones
Publisher
Korean Physiological Soc. and Korean Soc. of Pharmacology
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NF-κB) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-κB signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases. Copyright © Korean J Physiol Pharmacol & MEDrang Inc.
DOI
10.4196/kjpp.2015.19.3.269
Appears in Collections:
약학대학 > 약학과 > Journal papers
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