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Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants
- Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants
- Kwon Y.E.; Kim H.; Oh H.J.; Park J.T.; Han S.H.; Ryu D.-R.; Yoo T.-H.; Kang S.-W.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Medicine (United States)
- Medicine (United States) vol. 94, no. 9, pp. e594
- Lippincott Williams and Wilkins
- SCI; SCIE; SCOPUS
- Document Type
- Vitamin D deficiency is frequently found in patients with renal transplants (RTxs). Because vitamin D plays indispensable roles in the immune system, there may be an association between vitamin D deficiency and infection in these patients, but this has not been fully elucidated. Therefore, this study investigated the impact of pre-RTx vitamin D deficiency on urinary tract infection (UTI) development after RTx. We measured 25-hydroxyvitamin D3 (25(OH)D3) levels in 410 patients 2 weeks before they underwent RTx. Vitamin D deficiency was defined as 25(OH)D3 <10ng/mL. The primary outcome was UTI occurrence after RTx. Cox proportional hazard analysis determined whether vitamin D deficiency was independently associated with UTI. The mean 25(OH)D3 level was 12.8±6.9ng/mL, and 171 patients (41.7%) were vitamin D deficient. During a median follow-up duration of 7.3 years, the UTI incidence was significantly higher in vitamin D-deficient patients (52 patients, 30.4%) compared with vitamin D-nondeficient patients (40 patients, 16.7%) (P=0.001). Moreover, multivariate Cox proportional hazard analysis showed that vitamin D deficiency was an independent predictor of UTI after RTx (hazard ratio 1.81, 95% confidence interval 1.11-2.97, P=0.02). Vitamin D deficiency was an independent risk factor for UTI after RTx; hence, determining 25(OH)D3 levels might help to predict infectious complications after RTx. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
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