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Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging

Title
Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging
Authors
Young Choi J.Kim G.-H.Guo Z.Yeon Lee H.Swamy K.M.K.Pai J.Shin S.Shin I.Yoon J.
Ewha Authors
윤주영K.M.K.Swamy
SCOPUS Author ID
윤주영scopus
Issue Date
2013
Journal Title
Biosensors and Bioelectronics
ISSN
0956-5663JCR Link
Citation
vol. 49, pp. 438 - 441
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The 4-propargylamino-1,8-naphthalimide based fluorescent probe 1 has been explored as a sensor for selective detection of Au3+. 4-Amino-1,8-naphthalimides, that possess typical intramolecular charge transfer (ICT) electronic characteristics, have been widely used as versatile platforms for fluorescent probes. The newly designed probe 1 contains a propargylamine moiety at C-4 of the naphthalimide chromophore that reacts with Au3+ to generate a product that has distinctly different electronic properties from 1. Specifically, the probe undergoes a remarkable change in its absorption spectrum upon addition of Au3+ that is associated with a distinct color change from yellow to light pink. In addition, a blue shift of ca. 56nm also takes place in the emission spectra of the probe. Consequently, 1 serves as a reaction-based sensor or so called chemodosimeter for Au3+. Importantly, surfactants enhance the rate of reaction of 1 with Au3+, thus, enhancing its use as a real time sensor. Finally, the results of studies probing its application to bioimaging of Au3+ in live cells show that the probe 1 has a unique ability to sense Au3+ in cells and, in particular, in lipid droplets within cells. © 2013 The Authors.
DOI
10.1016/j.bios.2013.05.033
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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