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LDH nanocontainers as bio-reservoirs and drug delivery carriers

Title
LDH nanocontainers as bio-reservoirs and drug delivery carriers
Authors
Oh J.-M.Park D.-H.Choi S.-J.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2012
Journal Title
Recent Patents on Nanotechnology
ISSN
1872-2105JCR Link
Citation
vol. 6, no. 3, pp. 200 - 217
Indexed
SCIE; SCOPUS WOS scopus
Abstract
This review outlines research and patents relating to the use of inorganic nanomaterial, layered double hydroxide, as nanocontainers for drug delivery and gene reservoirs. Various intercalative synthetic routes including coprecipitation, ion exchange, reconstruction and exfoliation-reassembly have been explored to incorporate drug or gene molecules. Its unique two-dimensional structure allows layered double hydroxide to act as a nanospace for the stabilization, targeted delivery or controlled release of gene or drug molecules. Intercalative hybrid nanomaterials have uses such as pharmaceutically active ingredients, in oral- or cellular delivery systems, cosmetic ingredients, molecular coding units and etc. Toxicological studies have found layered double hydroxides to be biocompatible compared with widely used nanoparticles such as iron oxide, silica, and single-walled carbon nanotubes. Due to their versatile functionality and biocompatibility, layered double hydroxides have been widely studied and their applicability can be expanded to other nanoparticle based bio-medical applications. © 2012 Bentham Science Publishers.
DOI
10.2174/187221012803531538
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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