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A 1μm diameter tip fiber-based surface plasmon resonance system for single unit optical neural recording

Title
A 1μm diameter tip fiber-based surface plasmon resonance system for single unit optical neural recording
Authors
Moon H.Kim S.A.Jun S.B.Lee J.Oh U.Kim S.J.
Ewha Authors
전상범
SCOPUS Author ID
전상범scopus
Issue Date
2011
Journal Title
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN
1557-170XJCR Link
Citation
pp. 498 - 500
Indexed
SCOPUS scopus
Abstract
A gold-deposited optical fiber sensor system based on surface plasmon resonance (SPR) was developed for optical measurement of neuronal activity. To enhance the sensitivity of localized SPR and to make a precise and safe contact with the cellular membrane, we designed a tapered optical probe of 1m diameter at the tip of the fiber. By wet etching and gold evaporating processes, pencil-shaped optical probes were successfully fabricated. The SPR system with the sharp optical probe was integrated with a conventional patch clamping system to realize a simultaneous optical and electrical recording on a single neuron. Although the shape of optical signal is not clear due to tiny change of intrinsic optical properties on the neuron, optical and electrical signals were simultaneously changed by capsaicin stimulation. Furthermore, our designed fiber probe can be applicable to localized optical stimulation as well as in vivo optical neuroprosthetic devices. © 2011 IEEE.
DOI
10.1109/IEMBS.2011.6090089
ISBN
9781424441211
Appears in Collections:
엘텍공과대학 > 전자공학과 > Journal papers
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