Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.other | OAK-13606 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229575 | - |
dc.description.abstract | Fatostatin, a recently discovered small molecule that inhibits activation of sterol regulatory element-binding protein (SREBP), blocks biosynthesis and accumulation of fat in obese mice. We synthesized and evaluated a series of fatostatin derivatives. Our structure-activity relationships led to the identification of N-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenyl) methanesulfonamide (24, FGH10019) as the most potent druglike molecule among the analogues tested. Compound 24 has high aqueous solubility and membrane permeability and may serve as a seed molecule for further development. © 2011 American Chemical Society. | - |
dc.language | English | - |
dc.title | Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins | - |
dc.type | Article | - |
dc.relation.issue | 13 | - |
dc.relation.volume | 54 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 4923 | - |
dc.relation.lastpage | 4927 | - |
dc.relation.journaltitle | Journal of Medicinal Chemistry | - |
dc.identifier.doi | 10.1021/jm200304y | - |
dc.identifier.scopusid | 2-s2.0-79960181626 | - |
dc.author.google | Kamisuki S. | - |
dc.author.google | Shirakawa T. | - |
dc.author.google | Kugimiya A. | - |
dc.author.google | Abu-Elheiga L. | - |
dc.author.google | Park Choo H.-Y. | - |
dc.author.google | Yamada K. | - |
dc.author.google | Shimogawa H. | - |
dc.author.google | Wakil S.J. | - |
dc.author.google | Uesugi M. | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |