Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.isbn | 9789898425379 | - |
dc.identifier.other | OAK-13605 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/229574 | - |
dc.description.abstract | The pre-osteoblastic cell responses on poly(ε-caprolactone)- organosiloxane nanocomposite containing silanol groups was carried out to find out the origin of its good osteogenic properties. A poly(ε-caprolactone)- organosiloxane nanocomposite containing silanol groups was synthesized through sol-gel method. The adhesion, proliferation and differentiation activities of pre-osteoblastic MC3T3-E1 cells were evaluated using scanning electron microscopy, confocal laser microscopy analysis, MTS assay, Western blotting of integrins (α5β1 and α3βv), ALP activity test, RT-PCR, and calcium content assays. Tissue culture plate was used as a control. Cell adhesion on poly(ε-caprolactone)-organosiloxane nanocomposite was similar to that on tissue culture plate. However, α5β1 integrin expression on poly(ε-caprolactone)-organosiloxane nanocomposite was higher than that on tissue culture plate whereas α3βv expression was similar to each other. Proliferation activity on poly(ε-caprolactone)-organosiloxane nanocomposite was lower than that on tissue culture plate whereas differentiation activity was much higher. Thus, it can be known that the excellent differentiation activity of MC3T3-E1 cells on poly(ε- caprolactone)-organosiloxane nanocomposite might be originated from their high α5β1 integrin expression. From the results, it can be concluded that poly(ε-caprolactone)-organosiloxane nanocomposite containing silanol groups made by solgel method has a good osteoblast responses. It means it has a potential to be used as a bone grafting material or tissue engineering scaffold material because of its apatite-forming ability, good bone cell responses, and osteoconductivity. | - |
dc.description.sponsorship | Inst. Syst. Technol. Inf., Control Commun. (INSTICC) | - |
dc.language | English | - |
dc.title | Pre-osteoblastic cell responses on poly (ε-caprolactone)- organosiloxane nanocomposite prepared by sol-gel method | - |
dc.type | Conference Paper | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 333 | - |
dc.relation.lastpage | 336 | - |
dc.relation.journaltitle | BIODEVICES 2011 - Proceedings of the International Conference on Biomedical Electronics and Devices | - |
dc.identifier.scopusid | 2-s2.0-79960165351 | - |
dc.author.google | Rhee S.-H. | - |
dc.author.google | Kang Y.-M. | - |
dc.author.google | Min B.-M. | - |
dc.author.google | Park W.H. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Kim H.J. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230201093329 | - |