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Cell penetrating peptides for tumor targeting

Title
Cell penetrating peptides for tumor targeting
Authors
Choi Y.S.Lee J.Y.Suh J.S.Lee S.J.Yang V.C.Chung C.P.Park Y.J.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2011
Journal Title
Current Pharmaceutical Biotechnology
ISSN
1389-2010JCR Link
Citation
vol. 12, no. 8, pp. 1166 - 1182
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy. While different types of transporters currently exist, cell penetrating peptides (CPPs) have become one of the most popular and effective tools for intracellular drug delivery. Most of the original CPPs are short peptides with basic residues. The mechanism of CPP cell entry remains to be established; however, the CPPs can deliver any type of molecular cargo including solid nanoparticles. Herein, this paper will discuss the classification of CPPs, the mechanism of cell entry, the application of CPPs in tumor therapy, and recent advances in targeted cell penetration that involve CPPs. © 2011 Bentham Science Publishers Ltd.
DOI
10.2174/138920111796117391
Appears in Collections:
약학대학 > 약학과 > Journal papers
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