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Environmental factors that affect Streptococcus mutans biofilm formation in a microfluidic device mimicking teeth

Title
Environmental factors that affect Streptococcus mutans biofilm formation in a microfluidic device mimicking teeth
Authors
Shumi W.Lim J.Nam S.-W.Lee K.Kim S.H.Kim M.-H.Cho K.-S.Park S.
Ewha Authors
조경숙박성수
SCOPUS Author ID
조경숙scopus
Issue Date
2010
Journal Title
Biochip Journal
ISSN
1976-0280JCR Link
Citation
vol. 4, no. 4, pp. 257 - 263
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Streptococcus mutans is the primary etiological agent responsible for dental caries. Microfluidic devices have been used to provide a level of control over bacterial microenvironments under laminar flow conditions. In this study, we used a microfluidic device packed with glass beads to simulate the interproximal space, which is the space between the teeth. In the device, the effects of environmental factors, such as sucrose and metal ions, on S. mutans attachment and biofilm formation were quantitatively measured using confocal laser scanning microscopy and atomic force microscopy. We determined that sucrose was required for both bacterial attachment and exopolysaccharide (EPS) production in S. mutans. These results suggest that the in vivo condition between the teeth was successfully mimicked and that the device is highly suitable for in situ monitoring of oral biofilms. © The Korean BioChip Society and Springer 2010.
DOI
10.1007/s13206-010-4401-8
Appears in Collections:
엘텍공과대학 > 환경공학전공 > Journal papers
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