View : 148 Download: 0

Effect of stress on the expression of Rho-kinase and collagen in rat bladder tissue

Title
Effect of stress on the expression of Rho-kinase and collagen in rat bladder tissue
Authors
Yoon H.Lee D.Chun K.Yoo J.
Ewha Authors
이동현윤하나
SCOPUS Author ID
이동현scopus; 윤하나scopus
Issue Date
2010
Journal Title
Korean Journal of Urology
ISSN
2005-6737JCR Link
Citation
Korean Journal of Urology vol. 51, no. 2, pp. 132 - 138
Indexed
SCOPUS; KCI scopus
Document Type
Article
Abstract
Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability. © The Korean Urological Association, 2010.
DOI
10.4111/kju.2010.51.2.132
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE