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Effect of stress on the expression of Rho-kinase and collagen in rat bladder tissue
- Title
- Effect of stress on the expression of Rho-kinase and collagen in rat bladder tissue
- Authors
- Yoon H.; Lee D.; Chun K.; Yoo J.
- Ewha Authors
- 이동현; 윤하나
- SCOPUS Author ID
- 이동현; 윤하나
- Issue Date
- 2010
- Journal Title
- Korean Journal of Urology
- ISSN
- 2005-6737
- Citation
- Korean Journal of Urology vol. 51, no. 2, pp. 132 - 138
- Indexed
- SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. Materials and Methods: A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group. Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p<0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p<0.01; collagen type I in the 28-day group, p<0.05; collagen type III in the 14-day and 28-day groups, p<0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p<0.05). Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability. © The Korean Urological Association, 2010.
- DOI
- 10.4111/kju.2010.51.2.132
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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