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Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells

Title
Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells
Authors
Min H.-Y.Song S.-H.Lee B.Kim S.Lee S.K.
Ewha Authors
이상국
Issue Date
2010
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
vol. 7, no. 2, pp. 409 - 414
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Based on the anti-inflammatory activity of phenanthroindolizidine alkaloids, the inhibitory effect of antofine and its analogues on lipopolysaccharide (LPS)-induced nitric oxide (NO) production was examined, and structure-activity relationships are discussed. Antofine and several analogues suppressed NO production in LPS-stimulated RAW 264.7 cells. The MeO group at C(2), and the bulkiness of the substituents at C(3) and C(6) in the phenanthrene ring might be critical for this effect. Besides, regulation of iNOS expression might be involved in the inhibitory effect of antofine on LPS-induced NO production in macrophage cells. © 2010 Verlag Helvetica Chimica Acta AG.
DOI
10.1002/cbdv.200900040
Appears in Collections:
약학대학 > 약학과 > Journal papers
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