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Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa

Title
Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa
Authors
Hong J.-Y.Nam J.-W.Seo E.-K.Lee S.K.
Ewha Authors
이상국서은경
SCOPUS Author ID
서은경scopus
Issue Date
2010
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363JCR Link
Citation
vol. 58, no. 2, pp. 234 - 237
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Two new daphnane-type diterpene esters, yuanhuahine (1) and yuanhualine (2), were isolated from the flowers of Daphne genkwa (Thymelaeaceae) along with three known diterpene esters, yuanhuacine (3), yuanhuadine (4), and yuanhuagine (5). Their structures were determined by a combination of 1D and 2D NMR experiments, including correlation spectroscopy (COSY), heteronuclear multiple quantum correlation (HMQC), heteronuclear multiple bond correlation (HMBC), and rotating frame Overhauser enhancement spectroscopy (ROESY) sequences, and mass spectrometry. All the isolated compounds were tested against A549 human lung cancer cells and MRC-5 human normal lung epithelial cells. Compounds 1-5 exhibited potent anti-proliferative effects against A549 lung cancer cells with IC50 values of 12-53 nM, whereas these compounds were relatively non-cytotoxic against MRC-5 normal lung epithelial cells. © 2010 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.58.234
Appears in Collections:
약학대학 > 약학과 > Journal papers
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