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Antioxidant, antiinflamatory, and antiproliferative activities of strawberry extracts

Title
Antioxidant, antiinflamatory, and antiproliferative activities of strawberry extracts
Authors
Hong J.-Y.Song S.-H.Park H.J.Cho Y.-J.Pyee J.-H.Lee S.K.
Ewha Authors
이상국박헌주
Issue Date
2008
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 16, no. 3, pp. 286 - 292
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Strawberry is widely consumed in diet and has been attracted much attention due to its potential for human health benefits. Strawberry contains a diverse range of phytochemicals but the biological activities with molecular mechanisms are poorly elucidated yet. In this study, the effects of the extracts of strawberry (Maehyang cultivar) on antioxidant, antiinflammatory, and antiproliferative potential against various cancer cells were investigated. The strawberry extracts (SE) of Maehyang cultivar showed 1,1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging activities. In addition, SE inhibited the growth of human colon (HCT-116), lung (A549), stomach (SNU-638) and fibrosarcoma (HT-1080) cancer cells. The strawberry extracts also exhibited the inhibitory effect on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and suppressed LPS-induced inducible nitric oxide synthase (iNOS) protein and mRNA expression in mouse macrophage RAW 264.7 cells. These findings suggest that the strawberry extracts (Maehyang cultivar) might have antioxidant, antiinflammotry, and anticancer activities.
DOI
10.4062/biomolther.2008.16.3.286
Appears in Collections:
약학대학 > 약학과 > Journal papers
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