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A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F

Title
A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F
Authors
Na Y.Cha J.-H.Yoon H.-G.Kwon Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2009
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363JCR Link
Citation
vol. 57, no. 6, pp. 607 - 609
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis. © 2009 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.57.607
Appears in Collections:
약학대학 > 약학과 > Journal papers
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