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약학대학
약학과
Journal papers
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A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F
Title
A concise synthesis of licochalcone E and its Regio-isomer, licochalcone F
Authors
Na Y.
;
Cha J.-H.
;
Yoon H.-G.
;
Kwon Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주
Issue Date
2009
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363
Citation
Chemical and Pharmaceutical Bulletin vol. 57, no. 6, pp. 607 - 609
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis. © 2009 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.57.607
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