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Reactivity of 7-dithiocarboxy-imidazo[2,1-b]thiazoliumbetaine with aliphatic alkylating agents

Title
Reactivity of 7-dithiocarboxy-imidazo[2,1-b]thiazoliumbetaine with aliphatic alkylating agents
Authors
Song J.W.Suh M.E.Yoo K.H.Park S.W.
Ewha Authors
서명은
SCOPUS Author ID
서명은scopus
Issue Date
1989
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 12, no. 1, pp. 17 - 21
Publisher
Pharmaceutical Society of Korea
Indexed
SCIE; SCOPUS; KCI scopus
Abstract
We have reported earlier on the reactivity of 7-dithiocarboxy-3-phenyl-5,6-dihydro imidazo[2,1-b]thiazolium-betaine with several para-substituted phenacyl bromides. In this work reactions of 7-dithiocarboxy-3-phenyl(or methyl)-5,6-dihydro imidazo[2,1-b]thiazolium-betaine with a series of aliphatic alkylating agents of α-halo ketone, γ-halo keto ester and α-halo ester were examined for the similar purpose. In case of α-halo ketone or γ-halo keto ester such as α-chloro acetone or ethyl 4-chloro acetoacetate new biheterocyclic compound was obtained via ring transformation reaction. However, reaction of the betaine with methyl(or ethyl) bromoacetate used as a α-halo ester, gave, instead, S-alkylated quarternary ammonium salt. © 1989 The Pharmaceutical Society of Korea.
DOI
10.1007/BF02855740
Appears in Collections:
약학대학 > 약학과 > Journal papers
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