Induction of G 2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells

Abstract

A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N- methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G 2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). © 2004 Elsevier Ltd. All rights reserved.