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Induction of G 2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells

Title
Induction of G 2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells
Authors
Lee E.-J.Lee H.-J.Park H.J.Min H.-Y.Suh M.-E.Chung H.-J.Lee S.K.
Ewha Authors
이상국
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 14, no. 20, pp. 5175 - 5178
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N- methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G 2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). © 2004 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2004.07.062
Appears in Collections:
약학대학 > 약학과 > Journal papers
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