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Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation

Title
Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation
Authors
Hsieh M.Lee D.Panigone S.Horner K.Chen R.Theologis A.Lee D.C.Threadgill D.W.Conti M.
Ewha Authors
이대기
SCOPUS Author ID
이대기scopus
Issue Date
2007
Journal Title
Molecular and Cellular Biology
ISSN
0270-7306JCR Link
Citation
vol. 27, no. 5, pp. 1914 - 1924
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
In the preovulatory ovarian follicle, mammalian oocytes are maintained in prophase meiotic arrest until the luteinizing hormone (LH) surge induces reentry into the first meiotic division. Dramatic changes in the somatic cells surrounding the oocytes and in the follicular wall are also induced by LH and are necessary for ovulation. Here, we provide genetic evidence that LH-dependent transactivation of the epidermal growth factor receptor (EGFR) is indispensable for oocyte reentry into the meiotic cell cycle, for the synthesis of the extracellular matrix surrounding the oocyte that causes cumulus expansion, and for follicle rupture in vivo. Mice deficient in either amphiregulin or epiregulin, two EGFR ligands, display delayed or reduced oocyte maturation and cumulus expansion. In compound-mutant mice in which loss of one EGFR ligand is associated with decreased signaling from a hypomorphic allele of the EGFR, LH no longer signals oocyte meiotic resumption. Moreover, induction of genes involved in cumulus expansion and follicle rupture is compromised in these mice, resulting in impaired ovulation. Thus, these studies demonstrate that LH induction of epidermal growth factor-like growth factors and EGFR transactivation are essential for the regulation of a critical physiological process such as ovulation and provide new strategies for manipulation of fertility. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
DOI
10.1128/MCB.01919-06
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자연과학대학 > 생명과학전공 > Journal papers
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