Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 강상원 | * |
dc.date.accessioned | 2016-08-28T11:08:29Z | - |
dc.date.available | 2016-08-28T11:08:29Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0903-4641 | * |
dc.identifier.other | OAK-12854 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228919 | - |
dc.description.abstract | Peroxiredoxins (Prxs) 1-6 were assessed in 138 renal cell carcinomas (RCC) using immunohistochemistry and selected samples by Western blotting analysis. Oxidative/nitrosative damage was evaluated using nitrotyrosine immunoreactivity. The expressions of Prxs were correlated with tumor grade and survival and nitrotyrosine reactivity. Non-malignant kidney tubular cells showed positivity with variable intensity for all six Prxs. In RCCs, most cases were positive for Prxs 1 and 2, while only 15-20% of tumors showed expression for Prxs 3 and 4. Prx 2 was associated with tumors of a lower grade (p=0.009) and with a lower frequency of distant metastases (p=0.046). Patients with tumors expressing Prx2 had better prognosis (p=0.027). Instead, nitrotyrosine was significantly associated with high grade tumors (p=0.001). Compared with the non-malignant kidney tubular cells, low Prx expression in the tumor cells can make them more susceptible to oxidative damage. Prx 2 was more abundantly expressed in low grade tumors, suggesting that this protein could play a role in preventing the development of oxidative damage, which in turn can lead to the activation of pathways leading to aggressive tumors. © 2006 The Authors. | * |
dc.language | English | * |
dc.title | Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 114 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 329 | * |
dc.relation.lastpage | 337 | * |
dc.relation.journaltitle | APMIS | * |
dc.identifier.doi | 10.1111/j.1600-0463.2006.apm_315.x | * |
dc.identifier.wosid | WOS:000237811800002 | * |
dc.identifier.scopusid | 2-s2.0-33744821376 | * |
dc.author.google | Soini Y. | * |
dc.author.google | Kallio J.P. | * |
dc.author.google | Hirvikoski P. | * |
dc.author.google | Helin H. | * |
dc.author.google | Kellokumpu-Lehtinen P. | * |
dc.author.google | Kang S.W. | * |
dc.author.google | Tammela T.L.J. | * |
dc.author.google | Peltoniemi M. | * |
dc.author.google | Martikainen P.M. | * |
dc.author.google | Kinnula V.L. | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.date.modifydate | 20240118155300 | * |