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A facile synthesis of 2-aminothiazolo[5,4-b]pyridines and2-aminobanzoxazoles via cyclization of thioureas

Title
A facile synthesis of 2-aminothiazolo[5,4-b]pyridines and2-aminobanzoxazoles via cyclization of thioureas
Authors
Yoon J.H.Song H.Kim S.W.Han G.Choo H.-Y.P.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2005
Journal Title
Heterocycles
ISSN
0385-5414JCR Link
Citation
vol. 65, no. 11, pp. 2729 - 2740
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
2-Aminothiazolo[5,4-b]pyridines and 2-aminobenzoxazoles havebeen synthesized from 2-hydroxy-3-thioureidopyridine and 2-hydroxy-3-thioureidobenzene respectively via acid catalyzed cyclization, which were prepared by the reaction of isothiocyanates with 2-hydroxy-3-aminopyridine or 2-aminophenol. The hydroxyl group of N-(2-hydroxy-5-phenyl)-N′-phenyl thiourea reacted as nucleophile to thioureido carbon to give 2-aminobenzoxazoles, whereas that of N-(2-hydroxypyridino)-N′-phenylthiourea was reacted as leaving group upon nuclephillic sulfur of thiourea group in the presence of trifluoroacetic acid or phosphoric acid. © 2005 The Japan Institute of Heterocyclic Chemistry.
DOI
10.3987/COM-05-10440
Appears in Collections:
약학대학 > 약학과 > Journal papers
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