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Energetics of rotational gating mechanisms of an ion channel induced by membrane deformation

Title
Energetics of rotational gating mechanisms of an ion channel induced by membrane deformation
Authors
Lee K.-J.-B.
Ewha Authors
이공주복
SCOPUS Author ID
이공주복scopus
Issue Date
2006
Journal Title
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
ISSN
1539-3755JCR Link
Citation
vol. 73, no. 2
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We consider the gating mechanisms of an ion channel which has a conical structure for a closed state and a cylindrical or a bottleneck structure for an open state depending on the gating mechanisms. Applying the simplified continuum model of the membrane in the presence of a strong hydrophobic interaction between the channel proteins and the nearby lipid molecules of the membrane, we obtain energy differences between closed and open states for two known and one newly proposed rotational gating mechanism. We compare the energetics of three gating mechanisms and find out the most favorable mechanism under the given biological conditions such as hydrophobic mismatch, spontaneous curvature of a monolayer, and membrane moduli in our approach. Our results show that spontaneous curvature plays more important role in these gating mechanisms than surface tension does. Introducing spontaneous curvature to the inner or outer layer of the membrane affects the gating mechanism. We also discuss an effect of membrane thickness change due to the channel's conformational transition during gating. © 2006 The American Physical Society.
DOI
10.1103/PhysRevE.73.021909
Appears in Collections:
자연과학대학 > 물리학전공 > Journal papers
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