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T-bet-dependent expression of osteopontin contributes to T cell polarization

Title
T-bet-dependent expression of osteopontin contributes to T cell polarization
Authors
Shinohara M.L.Jansson M.Hwang E.S.Werneck M.B.F.Glimcher L.H.Cantor H.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2005
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424JCR Link
Citation
vol. 102, no. 47, pp. 17101 - 17106
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through differential regulation of IL-12 and IL-10 cytokine gene expression in macrophages. Although Opn has been suggested to play a role in the development of type-1 immunity, little is known about control of Opn gene expression. Here, we report that Opn gene expression in activated T cells, but not macrophages, is regulated by T-bet, a transcription factor that controls CD4 + T helper (Th1) cell lineage commitment. We also find that T-bet-dependent expression of Opn in T cells is essential for efficient skewing of CD4 + T and CD8 + T cells toward the Th1 and type 1 CD8 + T cells (Tc1) pathway, respectively. Taken together, these findings begin to delineate the genetic basis of Opn expression in T cells and further clarify the role of Opn in Th and Tc1 development. © 2005 by The National Academy of Sciences of the USA.
DOI
10.1073/pnas.0508666102
Appears in Collections:
약학대학 > 약학과 > Journal papers
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