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Inhibition of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative, SCOH

Title
Inhibition of osteoclast differentiation and bone resorption by a novel lysophosphatidylcholine derivative, SCOH
Authors
Kwak H.B.Lee S.W.Li Y.-J.Kim Y.-A.Han S.-Y.Jhon G.-J.Kim H.-H.Lee Z.H.
Ewha Authors
전길자한소엽
SCOPUS Author ID
전길자scopus; 한소엽scopus
Issue Date
2004
Journal Title
Biochemical Pharmacology
ISSN
0006-2952JCR Link
Citation
vol. 67, no. 7, pp. 1239 - 1248
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Osteoclasts are multinucleated cells formed by multiple steps of cell differentiation from progenitor cells of hematopoietic origin. Intervention in osteoclast differentiation is considered as an effective therapeutic approach to the treatment for bone diseases involving osteoclasts. In this study, we found that the organic compound (S)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3- phosphatidylcholine (SCOH) inhibited osteoclast differentiation. The inhibitory effect of SCOH was observed in mouse bone marrow cell cultures supported either by coculturing with osteoblasts or by adding macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANKL). M-CSF and RANKL activate the ERK, Akt, and NF-κB signal transduction pathways, and SCOH suppressed this activation. SCOH also inhibited the bone resorptive activity of differentiated osteoclasts. It attenuated bone resorption, actin ring formation, and survival of mature osteoclasts. Reduced activation of Akt and NF-κB and decreased induction of XIAP were observed in mature osteoclasts treated with SCOH. Thus, this novel phosphatidylcholine derivative may be useful for treating bone-resorption diseases. © 2004 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bcp.2003.10.032
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자연과학대학 > 화학·나노과학전공 > Journal papers
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