Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최철희 | - |
dc.date.accessioned | 2016-08-28T11:08:11Z | - |
dc.date.available | 2016-08-28T11:08:11Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.other | OAK-12668 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228754 | - |
dc.description.abstract | FasL has been shown to induce angiogenesis in vivo, however, the mechanism remains to be determined. We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL. Intercellular adhesion molecule (ICAM)-1 is increased in various human tumors, and is thought to be involved in the processes of metastasis and angiogenesis. We demonstrate that Fas ligation induces ICAM-1 expression at the mRNA and protein levels in human astroglioma cells. Studies using Boc-D-Fmk, a pharmacological inhibitor, show that caspase activation is required for Fas-mediated ICAM-1 induction. To study the in vivo expression of Fas and ICAM-1, human low-grade astrogliomas and glioblastoma multiforme (GBM) samples were examined by ELISA for Fas and ICAM-1. Human GBM samples express higher levels of Fas compared to normal control brain, which correlates with increased ICAM-1 expression. These findings suggest that Fas ligation on human glioma cells leads to the induction of ICAM-1 expression, which involves caspase cascade signaling pathways. © 2003 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Induction of intercellular adhesion molecule-1 by Fas ligation: Proinflammatory roles of Fas in human astroglioma cells | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 352 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 21 | - |
dc.relation.lastpage | 24 | - |
dc.relation.journaltitle | Neuroscience Letters | - |
dc.identifier.doi | 10.1016/j.neulet.2003.08.019 | - |
dc.identifier.wosid | WOS:000186689600006 | - |
dc.identifier.scopusid | 2-s2.0-0242459197 | - |
dc.author.google | Choi K. | - |
dc.author.google | Benveniste E.N. | - |
dc.author.google | Choi C. | - |
dc.contributor.scopusid | 최철희(55574827700) | - |
dc.date.modifydate | 20211210152234 | - |