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Effects of radioprotective ginseng protein on UV induced sister chromatid exchanges

Title
Effects of radioprotective ginseng protein on UV induced sister chromatid exchanges
Authors
Kim C.Choi J.-E.
Ewha Authors
김춘미
SCOPUS Author ID
김춘미scopus
Issue Date
1988
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 11, no. 2, pp. 93 - 98
Publisher
Pharmaceutical Society of Korea
Indexed
SCIE; SCOPUS; KCI scopus
Abstract
To elucidate the reaction mechanism of ginseng protein on its antiradiation activity, its effects were studied on sister chromatid exchanges (SCE) induced by UV irradiation in CHO-Kl cells. When cells were irradiated with 254 nm UV light at the dose of 0 to 80 erg/mm2, the frequencies of SCE were increased more than two fold. However, when radio-protective ginseng protein was added to the cells before and after UV irradiation, SCE frequencies were decreased significantly at all UV doses in both cases with no significant differences. As the amount of ginseng protein was varied from 100 to 500 μg/ml, with UV irradiation at 60 erg/mm2, SCE frequencies dropped sharply at the first two concentrations and then reached a sort of plateau in both cases of pre-and post-treatment. When the ginseng protein was treated alone without UV irradiation, there were no changes in SCE frequencies no matter when the protein was added. These results suggest that the ginseng protein could reduce DNA damages, which may play an important role in the reaction mechanism of radioprotective activity of the protein. © 1988 The Pharmaceutical Society of Korea.
DOI
10.1007/BF02857711
Appears in Collections:
약학대학 > 약학과 > Journal papers
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