Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김원기 | - |
dc.date.accessioned | 2016-08-28T11:08:39Z | - |
dc.date.available | 2016-08-28T11:08:39Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.other | OAK-12597 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/228695 | - |
dc.description.abstract | Pretreatment of interferon-γ and lipopolysaccharides made C6 glioma cells highly vulnerable to glucose deprivation. Neither 12 h of glucose deprivation nor 2-day treatment with interferon-γ (100 U/ml) and lipopolysaccharides (1 μg/ml) altered the viability of C6 glioma cells. However, significant death of immunostimulated C6 glioma cells was observed after 5 h of glucose deprivation. The augmented death was prevented by dehydroepiandrosterone (DHEA) treatment during immunostimulation, but not by DHEA treatment during glucose deprivation. DHEA reduced the rise in nitrotyrosine immunoreactivity, a marker of peroxynitrite, and superoxide production in glucose-deprived immunostimulated C6 glioma cells. DHEA, however, did not protect glucose-deprived C6 glioma cells from the exogenously produced peroxynitrite by 3-morpholinosydnonimine. Further, DHEA did not alter the production of total reactive oxygen species and nitric oxide in immunostimulated C6 glioma cells. Superoxide dismutase (SOD) and the synthetic SOD mimetic Mn(III)tetrakis (4-benzoic acid) porphyrin inhibited the death of glucose-deprived immunostimulated C6 glioma cells. In addition, a superoxide anion generator paraquat reversed the protective effect of DHEA on the augmented death. The data indicate that DHEA prevents the glucose deprivation-evoked augmented death by inhibiting the production of superoxide anion in immunostimulated C6 glioma cells. © 2001 Elsevier Science B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 922 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 267 | - |
dc.relation.lastpage | 275 | - |
dc.relation.journaltitle | Brain Research | - |
dc.identifier.doi | 10.1016/S0006-8993(01)03185-7 | - |
dc.identifier.wosid | WOS:000173457000014 | - |
dc.identifier.scopusid | 2-s2.0-0035924367 | - |
dc.author.google | Young Shin C. | - |
dc.author.google | Choi J.-W. | - |
dc.author.google | Sook Jang E. | - |
dc.author.google | Ju C. | - |
dc.author.google | Kim W.-K. | - |
dc.author.google | Kim H.-C. | - |
dc.author.google | Choi C.-R. | - |
dc.author.google | Ho Ko K. | - |
dc.contributor.scopusid | 김원기(34770946200) | - |
dc.date.modifydate | 20211210152058 | - |