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Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA: Cholesterol acyltransferase

Title
Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA: Cholesterol acyltransferase
Authors
Kwon B.-M.Ro S.-H.Kim M.-K.Nam J.-Y.Jung H.-J.Lee I.-R.Kim Y.-K.Bok S.-H.
Ewha Authors
이인란
SCOPUS Author ID
이인란scopusscopus
Issue Date
1997
Journal Title
Planta Medica
ISSN
0032-0943JCR Link
Citation
vol. 63, no. 6, pp. 552 - 553
Indexed
SCI; SCIE; SCOPUS scopus
Abstract
In the course of our screening program for acylCoA:cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC50 values of 94, 80, 45 and 79 μM, respectively.
DOI
10.1055/s-2006-957763
Appears in Collections:
약학대학 > 약학과 > Journal papers
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