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Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA: Cholesterol acyltransferase
- Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA: Cholesterol acyltransferase
- Kwon B.-M.; Ro S.-H.; Kim M.-K.; Nam J.-Y.; Jung H.-J.; Lee I.-R.; Kim Y.-K.; Bok S.-H.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Planta Medica
- vol. 63, no. 6, pp. 552 - 553
- SCI; SCIE; SCOPUS
- In the course of our screening program for acylCoA:cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC50 values of 94, 80, 45 and 79 μM, respectively.
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