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The antifungal activities of some 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinediones against Candida species

Title
The antifungal activities of some 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinediones against Candida species
Authors
Ryu C.-K.Kim D.-H.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
1994
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 17, no. 6, pp. 483 - 486
Indexed
SCIE; SCOPUS; KCI scopus
Abstract
A series of 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinedione derivatives 1-10 were tested for antifungal susceptibilities, in vitro, against pathogenic Candida species such as C. albicans, C. glabrata, C. krusei, C. parapsilosis and C. tropicalis. The MICs were determined by the standard macrodilution techniques, according to the NCCLS 1992 guidelines. The 6-[N-(halophenyl)amino]-7-chloro-5,8-quinolinedione derivatives showed generally potent antifungal activities against pathogenic Candida species. Among them, derivative 1, 2, 5 and 7 showed more potent antifungal activities than ketoconazole. All derivatives 1-10 had specially potent activities against C. tropicalis. Derivative 1 and 2 containing (N-3,4-dihalo-phenyl)amino moiety exhibited the potent antifungal activities. Derivative 2 with (3,4-dichlorophenyl)amino substituent was the most effective in preventing the growth of Candida species at MICs 4 μg/ml respectively. © 1994 The Pharmaceutical Society of Korea.
DOI
10.1007/BF02979131
Appears in Collections:
약학대학 > 약학과 > Journal papers
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