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Effect of biocompatible peritoneal dialysis solution on residual renal function: A systematic review of randomized controlled trials

Title
Effect of biocompatible peritoneal dialysis solution on residual renal function: A systematic review of randomized controlled trials
Authors
Seo E.-Y.An S.H.Cho J.-H.Suh H.S.Park S.-H.Gwak H.Kim Y.-L.Ha H.
Ewha Authors
하헌주곽혜선
SCOPUS Author ID
하헌주scopus; 곽혜선scopus
Issue Date
2014
Journal Title
Peritoneal Dialysis International
ISSN
0896-8608JCR Link
Citation
vol. 34, no. 7, pp. 724 - 731
Keywords
Peritoneal dialysis solutionsRandomized controlled trialsResidual renal functionSystematic review
Publisher
Multimed Inc.
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Introduction: Residual renal function (RRF) plays an important role in outcome of peritoneal dialysis (PD) including mortality. It is, therefore, important to provide a strategy for the preservation of RRF. The objective of this study was to evaluate relative protective effects of new glucose-based multicompartmental PD solution (PDS), which is well known to be more biocompatible than glucose-based conventional PDS, on RRF compared to conventional PDS by performing a systematic review (SR) of randomized controlled trials. Methods: We searched studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library, and local databases. Three independent reviewers reviewed and extracted prespecified data from each study. The random effects model, a more conservative analysis model, was used to combine trials and to perform stratified analyses based on the duration of follow-up. Study quality was assessed using the Cochrane Handbook for risk of bias. Eleven articles with 1,034 patients were identified for the SR. Results: The heterogeneity of the studies under 12 months was very high, and the heterogeneity decreased substantially when we stratified studies by the duration of follow-up. The mean difference of the studies after 12 months was 0.46 mL/min/1.73 m2 (95% confidence interval = 0.25 to + 0.67). Conclusion: New PDS showed the effect to preserve and improve RRF for long-term use compared to conventional PDS, even though it did not show a significant difference to preserve RRF for short-term use. © 2014 International Society for Peritoneal Dialysis.
DOI
10.3747/pdi.2012.00331
Appears in Collections:
약학대학 > 약학과 > Journal papers
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