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Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors

Title
Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors
Authors
Kim M.Lee J.Jung K.Kim H.Aman W.Ryu J.-S.Hah J.-M.
Ewha Authors
류재상
SCOPUS Author ID
류재상scopus
Issue Date
2014
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
1464-3405JCR Link
Citation
vol. 24, no. 15, pp. 3600 - 3604
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
(4-Aminobenzyl)-1H-imidazol-1-yl pyrimidin-2-yl derivatives; Antiproliferative activity; BRAF V600E; CRAF; Melanoma; Selectivity
DOI
10.1016/j.bmcl.2014.05.030
Appears in Collections:
약학대학 > 약학과 > Journal papers
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