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Administration of phytoceramide enhances memory and upregulatesthe expression of pCREB and BDNF in hippocampus of mice

Title
Administration of phytoceramide enhances memory and upregulatesthe expression of pCREB and BDNF in hippocampus of mice
Authors
Lee Y.Kim J.Jang S.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2013
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 21, no. 3, pp. 229 - 233
Indexed
SCIE; SCOPUS WOS scopus
Abstract
This study was aimed at investigating the possible effects of phytoceramide (Pcer) on learning and memory and their underlying mechanisms. Phytoceramide was orally administered to ICR mice for 7 days. Memory performances were assessed using the passive avoidance test and Y-maze task. The expressions of phosphorylated cAMP response element binding protein (pCREB), brain-derived neurotrophic factor (BDNF) were measured with immunoblot. The incorporation of 5-bromo-2-deoxyuridine (BrdU) in hippocampal regions was investigated by using immunohistochemical methods. Treatment of Pcer enhanced cognitive performances in the passive avoidance test and Y-maze task. Immunoblotting studies revealed that the phosphorylated CREB and BDNF were signifi cantly increased on hippocampus in the Pcer-treated mice. Immunohistochemical studies showed that the number of immunopositive cells to BrdU was signifi cantly increased in the hippocampal dentate gyrus regions after Pcer-treatment for 7 days. These results suggest that Pcer contribute to enhancing memory and BDNF expression and it could be secondary to the elevation of neurogenesis. © 2013 The Korean Society of Applied Pharmacology.
DOI
10.4062/biomolther.2013.002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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