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dc.contributor.author오세관-
dc.date.accessioned2016-08-28T11:08:29Z-
dc.date.available2016-08-28T11:08:29Z-
dc.date.issued2013-
dc.identifier.issn1976-9148-
dc.identifier.otherOAK-10905-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/227416-
dc.description.abstractThis study was aimed at investigating the possible effects of phytoceramide (Pcer) on learning and memory and their underlying mechanisms. Phytoceramide was orally administered to ICR mice for 7 days. Memory performances were assessed using the passive avoidance test and Y-maze task. The expressions of phosphorylated cAMP response element binding protein (pCREB), brain-derived neurotrophic factor (BDNF) were measured with immunoblot. The incorporation of 5-bromo-2-deoxyuridine (BrdU) in hippocampal regions was investigated by using immunohistochemical methods. Treatment of Pcer enhanced cognitive performances in the passive avoidance test and Y-maze task. Immunoblotting studies revealed that the phosphorylated CREB and BDNF were signifi cantly increased on hippocampus in the Pcer-treated mice. Immunohistochemical studies showed that the number of immunopositive cells to BrdU was signifi cantly increased in the hippocampal dentate gyrus regions after Pcer-treatment for 7 days. These results suggest that Pcer contribute to enhancing memory and BDNF expression and it could be secondary to the elevation of neurogenesis. © 2013 The Korean Society of Applied Pharmacology.-
dc.languageEnglish-
dc.titleAdministration of phytoceramide enhances memory and upregulatesthe expression of pCREB and BDNF in hippocampus of mice-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume21-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage229-
dc.relation.lastpage233-
dc.relation.journaltitleBiomolecules and Therapeutics-
dc.identifier.doi10.4062/biomolther.2013.002-
dc.identifier.wosidWOS:000329335300008-
dc.identifier.scopusid2-s2.0-84878468394-
dc.author.googleLee Y.-
dc.author.googleKim J.-
dc.author.googleJang S.-
dc.author.googleOh S.-
dc.contributor.scopusid오세관(7404103757)-
dc.date.modifydate20180329110743-
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의과대학 > 의학과 > Journal papers
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