Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-28T11:08:29Z | - |
dc.date.available | 2016-08-28T11:08:29Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.other | OAK-10905 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/227416 | - |
dc.description.abstract | This study was aimed at investigating the possible effects of phytoceramide (Pcer) on learning and memory and their underlying mechanisms. Phytoceramide was orally administered to ICR mice for 7 days. Memory performances were assessed using the passive avoidance test and Y-maze task. The expressions of phosphorylated cAMP response element binding protein (pCREB), brain-derived neurotrophic factor (BDNF) were measured with immunoblot. The incorporation of 5-bromo-2-deoxyuridine (BrdU) in hippocampal regions was investigated by using immunohistochemical methods. Treatment of Pcer enhanced cognitive performances in the passive avoidance test and Y-maze task. Immunoblotting studies revealed that the phosphorylated CREB and BDNF were signifi cantly increased on hippocampus in the Pcer-treated mice. Immunohistochemical studies showed that the number of immunopositive cells to BrdU was signifi cantly increased in the hippocampal dentate gyrus regions after Pcer-treatment for 7 days. These results suggest that Pcer contribute to enhancing memory and BDNF expression and it could be secondary to the elevation of neurogenesis. © 2013 The Korean Society of Applied Pharmacology. | * |
dc.language | English | * |
dc.title | Administration of phytoceramide enhances memory and upregulatesthe expression of pCREB and BDNF in hippocampus of mice | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 229 | * |
dc.relation.lastpage | 233 | * |
dc.relation.journaltitle | Biomolecules and Therapeutics | * |
dc.identifier.doi | 10.4062/biomolther.2013.002 | * |
dc.identifier.wosid | WOS:000329335300008 | * |
dc.identifier.scopusid | 2-s2.0-84878468394 | * |
dc.author.google | Lee Y. | * |
dc.author.google | Kim J. | * |
dc.author.google | Jang S. | * |
dc.author.google | Oh S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |