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Targeting cellular antioxidant enzymes for treating atherosclerotic vascular disease

Title
Targeting cellular antioxidant enzymes for treating atherosclerotic vascular disease
Authors
Kang D.H.Kang S.W.
Ewha Authors
강상원강동훈
SCOPUS Author ID
강상원scopus; 강동훈scopus
Issue Date
2013
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 21, no. 2, pp. 89 - 96
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerotic vascular disease. Intracellular redox status is tightly regulated by oxidant and antioxidant systems. Imbalance in these systems causes oxidative or reductive stress which triggers cellular damage or aberrant signaling, and leads to dysregulation. Paradoxically, large clinical trials have shown that non-specific ROS scavenging by antioxidant vitamins is ineffective or sometimes harmful. ROS production can be locally regulated by cellular antioxidant enzymes, such as superoxide dismutases, catalase, glutathione peroxidases and peroxiredoxins. Therapeutic approach targeting these antioxidant enzymes might prove beneficial for prevention of ROS-related atherosclerotic vascular disease. Conversely, the development of specific antioxidant enzyme-mimetics could contribute to the clinical effectiveness. © 2013 The Korean Society of Applied Pharmacology.
DOI
10.4062/biomolther.2013.015
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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