View : 24 Download: 0

Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents

Title
Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents
Authors
Nam J.-W.Kim S.-Y.Yoon T.Lee Y.J.Kil Y.-S.Lee Y.-S.Seo E.-K.
Ewha Authors
서은경이윤실윤태숙
SCOPUS Author ID
서은경scopus; 이윤실scopus
Issue Date
2013
Journal Title
Chemistry and Biodiversity
ISSN
1612-1872JCR Link
Citation
vol. 10, no. 7, pp. 1322 - 1327
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions. Among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of E. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside (1), bartsioside (2), and feretoside (3), which were found in the family Eucommiaceae for the first time. The compounds 1-3 were evaluated for their inducible activities on the heat shock factor 1 (HSF1), and heat shock proteins (HSPs) 27 and 70, along with four compounds, geniposide (4), geniposidic acid (5), pinoresinol diglucoside (6), and liriodendrin (7), which were previously reported from E. ulmoides. Compounds 1-7 increased expression of HSF1 by a factor of 1.214, 1.144, 1.153, 1.114, 1.159, 1.041, and 1.167 at 3 μM, respectively. Coniferaldehyde glucoside (1) showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose-dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.
DOI
10.1002/cbdv.201200401
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE