View : 13 Download: 0

A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB

Title
A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB
Authors
Shin J.-A.Hwang J.-S.Kim S.-Y.Oh S.-K.Nam G.Han I.-O.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2013
Journal Title
Neuroscience Letters
ISSN
0304-3940JCR Link
Citation
vol. 550, pp. 162 - 167
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Glucosamine suppresses lipopolysaccharide (LPS)-induced upregulation of pro-inflammatory mediators both in vivo and in culture systems of mouse microglia or macrophage. In the present study, we show that the novel glucosamine derivative, 2-deoxy-2-[(o-methylbenzylidene)]-β-glucopyranoside (NK-4), significantly reduced LPS-induced production of nitric oxide (NO) in BV2 microglia, RAW264.7 macrophage, and primary cultured peritoneal macrophages cells. NK-4 inhibited LPS-induced upregulation of inducible NO synthase (iNOS), cyclooxygenase-2, interleukin-6, tumor necrosis factor-α, and interleukin-1β in RAW264.7 cells in a time- and concentration-dependent manner. Furthermore, administering NK-4 significantly inhibited the induction of inflammatory cytokine mRNAs in the brains of LPS-injected mice. Although NK-4 inhibited LPS-induced nuclear factor-kappaB (NF-κB) activation, IκB-α degradation was not changed. Instead, NK-4 inhibited LPS-induced DNA-binding activity of NF-κB by suppressing p50 and c-Rel binding to NF-κB binding site of the iNOS promoter. © 2013 Elsevier Ireland Ltd.
DOI
10.1016/j.neulet.2013.06.053
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE