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dc.contributor.author오세관*
dc.date.accessioned2016-08-28T10:08:30Z-
dc.date.available2016-08-28T10:08:30Z-
dc.date.issued2013*
dc.identifier.issn0304-3940*
dc.identifier.otherOAK-10436*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/224027-
dc.description.abstractGlucosamine suppresses lipopolysaccharide (LPS)-induced upregulation of pro-inflammatory mediators both in vivo and in culture systems of mouse microglia or macrophage. In the present study, we show that the novel glucosamine derivative, 2-deoxy-2-[(o-methylbenzylidene)]-β-glucopyranoside (NK-4), significantly reduced LPS-induced production of nitric oxide (NO) in BV2 microglia, RAW264.7 macrophage, and primary cultured peritoneal macrophages cells. NK-4 inhibited LPS-induced upregulation of inducible NO synthase (iNOS), cyclooxygenase-2, interleukin-6, tumor necrosis factor-α, and interleukin-1β in RAW264.7 cells in a time- and concentration-dependent manner. Furthermore, administering NK-4 significantly inhibited the induction of inflammatory cytokine mRNAs in the brains of LPS-injected mice. Although NK-4 inhibited LPS-induced nuclear factor-kappaB (NF-κB) activation, IκB-α degradation was not changed. Instead, NK-4 inhibited LPS-induced DNA-binding activity of NF-κB by suppressing p50 and c-Rel binding to NF-κB binding site of the iNOS promoter. © 2013 Elsevier Ireland Ltd.*
dc.languageEnglish*
dc.titleA novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB*
dc.typeArticle*
dc.relation.volume550*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage162*
dc.relation.lastpage167*
dc.relation.journaltitleNeuroscience Letters*
dc.identifier.doi10.1016/j.neulet.2013.06.053*
dc.identifier.wosidWOS:000323851400031*
dc.identifier.scopusid2-s2.0-84881368229*
dc.author.googleShin J.-A.*
dc.author.googleHwang J.-S.*
dc.author.googleKim S.-Y.*
dc.author.googleOh S.-K.*
dc.author.googleNam G.*
dc.author.googleHan I.-O.*
dc.contributor.scopusid오세관(7404103757)*
dc.date.modifydate20240118133340*
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의과대학 > 의학과 > Journal papers
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