Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-28T10:08:30Z | - |
dc.date.available | 2016-08-28T10:08:30Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 0304-3940 | * |
dc.identifier.other | OAK-10436 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/224027 | - |
dc.description.abstract | Glucosamine suppresses lipopolysaccharide (LPS)-induced upregulation of pro-inflammatory mediators both in vivo and in culture systems of mouse microglia or macrophage. In the present study, we show that the novel glucosamine derivative, 2-deoxy-2-[(o-methylbenzylidene)]-β-glucopyranoside (NK-4), significantly reduced LPS-induced production of nitric oxide (NO) in BV2 microglia, RAW264.7 macrophage, and primary cultured peritoneal macrophages cells. NK-4 inhibited LPS-induced upregulation of inducible NO synthase (iNOS), cyclooxygenase-2, interleukin-6, tumor necrosis factor-α, and interleukin-1β in RAW264.7 cells in a time- and concentration-dependent manner. Furthermore, administering NK-4 significantly inhibited the induction of inflammatory cytokine mRNAs in the brains of LPS-injected mice. Although NK-4 inhibited LPS-induced nuclear factor-kappaB (NF-κB) activation, IκB-α degradation was not changed. Instead, NK-4 inhibited LPS-induced DNA-binding activity of NF-κB by suppressing p50 and c-Rel binding to NF-κB binding site of the iNOS promoter. © 2013 Elsevier Ireland Ltd. | * |
dc.language | English | * |
dc.title | A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB | * |
dc.type | Article | * |
dc.relation.volume | 550 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 162 | * |
dc.relation.lastpage | 167 | * |
dc.relation.journaltitle | Neuroscience Letters | * |
dc.identifier.doi | 10.1016/j.neulet.2013.06.053 | * |
dc.identifier.wosid | WOS:000323851400031 | * |
dc.identifier.scopusid | 2-s2.0-84881368229 | * |
dc.author.google | Shin J.-A. | * |
dc.author.google | Hwang J.-S. | * |
dc.author.google | Kim S.-Y. | * |
dc.author.google | Oh S.-K. | * |
dc.author.google | Nam G. | * |
dc.author.google | Han I.-O. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |