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Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin

Title
Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin
Authors
Hansen D.A.Rath C.M.Eisman E.B.Narayan A.R.H.Kittendorf J.D.Mortison J.D.Yoon Y.J.Sherman D.H.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2013
Journal Title
Journal of the American Chemical Society
ISSN
0002-7863JCR Link
Citation
vol. 135, no. 30, pp. 11232 - 11238
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A biocatalytic platform that employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro followed by direct appendage of d-desosamine and final C-H oxidation(s) in vivo was developed and applied toward the synthesis of a suite of 12- and 14-membered ring macrolide natural products. This methodology delivered both compound classes in 13 steps (longest linear sequence) from commercially available (R)-Roche ester in >10% overall yields. © 2013 American Chemical Society.
DOI
10.1021/ja404134f
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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