Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정낙신 | - |
dc.date.accessioned | 2016-08-28T10:08:20Z | - |
dc.date.available | 2016-08-28T10:08:20Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-10327 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223928 | - |
dc.description.abstract | Although A3AR agonists exhibit a variety of biological activities including anticancer effects, their possible anti-angiogenic effects have not yet been investigated. In the present study, we assayed the anti-angiogenic activity of thio-Cl-IB-MECA, a novel A3AR agonist, in cultured HUVECs and mES/EB-derived endothelial cells. Thio-Cl-IB-MECA inhibited migration and tube formation by endothelial cells and dramatically decreased ex vivo microvessel sprouting in cultured mouse aortic rings. The anti-angiogenic activity of thio-Cl-IB-MECA was associated with suppression of the expression of the endothelial biomarker PECAM via regulation of PI3K/AKT/mTOR and ERK signaling in mES/EB-derived endothelial cells. © 2013 Elsevier Inc. | - |
dc.language | English | - |
dc.title | Thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, suppresses angiogenesis by regulating PI3K/AKT/mTOR and ERK signaling in endothelial cells | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 437 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 79 | - |
dc.relation.lastpage | 86 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.06.040 | - |
dc.identifier.wosid | WOS:000322353000014 | - |
dc.identifier.scopusid | 2-s2.0-84880506278 | - |
dc.author.google | Kim G.D. | - |
dc.author.google | Oh J. | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Lee S.K. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.date.modifydate | 20211210153610 | - |