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Ratiometric fluorescent probes for detection of intracellular singlet oxygen

Title
Ratiometric fluorescent probes for detection of intracellular singlet oxygen
Authors
Song D.Cho S.Han Y.You Y.Nam W.
Ewha Authors
남원우
SCOPUS Author ID
남원우scopus
Issue Date
2013
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 15, no. 14, pp. 3582 - 3585
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (1O2). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with 1O2, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous 1O2 in macrophage cells. © 2013 American Chemical Society.
DOI
10.1021/ol401421r
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자연과학대학 > 화학·나노과학전공 > Journal papers
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