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Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration

Title
Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration
Authors
Ban Y.H.Shinde P.B.Hwang J.-Y.Song M.-C.Kim D.H.Lim S.-K.Sohng J.K.Yoon Y.J.
Ewha Authors
윤여준송명종Pramod B. Shinde
SCOPUS Author ID
윤여준scopus; 송명종scopus
Issue Date
2013
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 76, no. 6, pp. 1091 - 1098
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The post-PKS modification steps of FK506 biosynthesis include C9-oxidation and 31-O-methylation, but the sequence of these reactions and the exact route have remained unclear. This study details the post-PKS modification pathways in FK506 biosynthesis through the identification of all intermediates and in vitro enzymatic reactions of the cytochrome P450 hydroxylase FkbD and the methyltransferase FkbM. These results complete our understanding of post-PKS modification steps to FK506 showing the substrate flexibility of two enzymes involved and the existence of two parallel biosynthetic routes to FK506. © 2013 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np4001224
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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