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Neu2000 potentiates a kainate response in mouse cortical neurons

Title
Neu2000 potentiates a kainate response in mouse cortical neurons
Authors
Noh J.Chung J.-M.
Ewha Authors
정준모노지현
SCOPUS Author ID
정준모scopus
Issue Date
2013
Journal Title
Journal of Pharmacological Sciences
ISSN
1347-8613JCR Link
Citation
vol. 122, no. 2, pp. 149 - 152
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Neu2000, acting as an antioxidant with N-methyl-D-aspartate-receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels. © 2013 The Japanese Pharmacological Society.
DOI
10.1254/jphs.13023SC
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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