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Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes

Title
Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes
Authors
Song M.C.Kim E.Ban Y.H.Yoo Y.J.Kim E.J.Park S.R.Pandey R.P.Sohng J.K.Yoon Y.J.
Ewha Authors
윤여준송명종
SCOPUS Author ID
윤여준scopus; 송명종scopus
Issue Date
2013
Journal Title
Applied Microbiology and Biotechnology
ISSN
0175-7598JCR Link
Citation
vol. 97, no. 13, pp. 5691 - 5704
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Bioactive natural products, such as polyketides, flavonoids, glycopeptides, and aminoglycosides, have been used as therapeutic agents. Many of them contain structurally diverse sugar moieties attached to the aglycone core structures. Glycosyltransferases (GTs) catalyze the attachment of nucleotide-activated sugar substrates to acceptor aglycones. Because these sugar moieties are usually essential for biological activity, in vivo pathway engineering in prokaryotic hosts and in vitro enzymatic approaches coupled with GT engineering are currently being used to synthesize novel glycosylated derivatives, and some of them exhibited improved biological activities compared to the parent molecules. Therefore, harnessing the potential of diverse glycosylation reactions in prokaryotes will increase the structural diversity of natural products and the possibility to generate new bioactive products. © 2013 Springer-Verlag Berlin Heidelberg.
DOI
10.1007/s00253-013-4978-7
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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