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Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes
- Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes
- Song M.C.; Kim E.; Ban Y.H.; Yoo Y.J.; Kim E.J.; Park S.R.; Pandey R.P.; Sohng J.K.; Yoon Y.J.
- Ewha Authors
- 윤여준; 송명종
- SCOPUS Author ID
- 윤여준; 송명종
- Issue Date
- Journal Title
- Applied Microbiology and Biotechnology
- Applied Microbiology and Biotechnology vol. 97, no. 13, pp. 5691 - 5704
- SCI; SCIE; SCOPUS
- Document Type
- Bioactive natural products, such as polyketides, flavonoids, glycopeptides, and aminoglycosides, have been used as therapeutic agents. Many of them contain structurally diverse sugar moieties attached to the aglycone core structures. Glycosyltransferases (GTs) catalyze the attachment of nucleotide-activated sugar substrates to acceptor aglycones. Because these sugar moieties are usually essential for biological activity, in vivo pathway engineering in prokaryotic hosts and in vitro enzymatic approaches coupled with GT engineering are currently being used to synthesize novel glycosylated derivatives, and some of them exhibited improved biological activities compared to the parent molecules. Therefore, harnessing the potential of diverse glycosylation reactions in prokaryotes will increase the structural diversity of natural products and the possibility to generate new bioactive products. © 2013 Springer-Verlag Berlin Heidelberg.
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