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A simple and efficient strategy for the sensitivity enhancement of DNA hybridization based on the coupling between propagating and localized surface plasmons

Title
A simple and efficient strategy for the sensitivity enhancement of DNA hybridization based on the coupling between propagating and localized surface plasmons
Authors
Chung K.Lee J.Lee J.-E.Lee J.Y.Moon S.Lau K.H.A.Kim D.Kim D.H.
Ewha Authors
김동하
SCOPUS Author ID
김동하scopus
Issue Date
2013
Journal Title
Sensors and Actuators, B: Chemical
ISSN
0925-4005JCR Link
Citation
vol. 176, pp. 1074 - 1080
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
This study demonstrates a simple and efficient strategy for the sensitivity improvement in detection of biomolecules via surface plasmon resonance field enhancement in a Kretschmann configuration. Synergistic coupling effects between propagating and localized surface plasmons (SPs) were demonstrated by incorporating arrays of Au nanoparticles (AuNPs) in-between DNA sensing assays. AuNPs with 5 nm or 15 nm diameter were incorporated respectively on the top of the streptavidin layer, and the couplinginduced sensitivity enhancement was systematically investigated. Uniform dispersion of AuNPs was confirmed by TEM analysis. The overall sensing capability of each system was investigated in terms of the reflectivity change, angular shift, and affinity constant for the DNA hybridization process and it was found that AuNP-arrays with appropriate size and lateral distribution led to the best efficiency. The experimental results were in good agreement with numerical simulation data based on a rigorous coupled wave analysis (RCWA). © 2012 Elsevier B.V. All rights reserved.
DOI
10.1016/j.snb.2012.10.025
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자연과학대학 > 화학·나노과학전공 > Journal papers
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