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Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform

Title
Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform
Authors
Mandal B.Bhattacharjee H.Mittal N.Sah H.Balabathula P.Thoma L.A.Wood G.C.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2013
Journal Title
Nanomedicine: Nanotechnology, Biology, and Medicine
ISSN
1549-9634JCR Link
Citation
vol. 9, no. 4, pp. 474 - 491
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core-shell architecture using a single delivery system to combine multiple functionalities within nanoparticles. Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs), which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. In CSLPHNs, a biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on CSLPHNs including classification, advantages, methods of preparation, physicochemical characteristics, surface modifications, and immunocompatibility. Additionally, the review deals with applications for cancer chemotherapy, vaccines, and gene therapeutics. From the Clinical Editor: This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system. © 2013 Elsevier Inc.
DOI
10.1016/j.nano.2012.11.010
Appears in Collections:
약학대학 > 약학과 > Journal papers
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