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Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours

Title
Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours
Authors
Sim H.-R.Choi T.-Y.Lee H.J.Kang E.Y.Yoon S.Han P.-L.Choi S.-Y.Baik J.-H.
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2013
Journal Title
Nature Communications
ISSN
2041-1723JCR Link
Citation
vol. 4
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Dopaminergic systems are implicated in stress-related behaviour. Here we investigate behavioural responses to chronic stress in dopamine D2 receptor knockout mice and find that anxiety-like behaviours are increased compared with wild-type mice. Repeated stress exposure suppresses cocaine-induced behavioural sensitization, cocaine-seeking and relapse behaviours in dopamine D2 receptor knockout mice. Cocaine challenge after drug withdrawal in cocaine-experienced wild-type or dopamine D2 receptor knockout mice is associated with inhibition of long-term depression in the nucleus accumbens, and chronic stress during withdrawal prevents inhibition after cocaine challenge in cocaine-experienced dopamine D2 receptor knockout mice, but not in wild-type mice. Lentiviral-induced knockdown of dopamine D2 receptors in the nucleus accumbens of wild-type mice does not affect basal locomotor activity, but confers stress-induced inhibition of the expression of cocaine-induced behavioural sensitization. Stressed mice depleted of dopamine D2 receptors do not manifest long-term depression inhibition. Our results suggest that dopamine D2 receptors have roles in regulating synaptic modification triggered by stress and drug addiction. © 2013 Macmillan Publishers Limited. All rights reserved.
DOI
10.1038/ncomms2598
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