Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2016-08-28T10:08:58Z | - |
dc.date.available | 2016-08-28T10:08:58Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | OAK-10090 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223729 | - |
dc.description.abstract | Dopaminergic systems are implicated in stress-related behaviour. Here we investigate behavioural responses to chronic stress in dopamine D2 receptor knockout mice and find that anxiety-like behaviours are increased compared with wild-type mice. Repeated stress exposure suppresses cocaine-induced behavioural sensitization, cocaine-seeking and relapse behaviours in dopamine D2 receptor knockout mice. Cocaine challenge after drug withdrawal in cocaine-experienced wild-type or dopamine D2 receptor knockout mice is associated with inhibition of long-term depression in the nucleus accumbens, and chronic stress during withdrawal prevents inhibition after cocaine challenge in cocaine-experienced dopamine D2 receptor knockout mice, but not in wild-type mice. Lentiviral-induced knockdown of dopamine D2 receptors in the nucleus accumbens of wild-type mice does not affect basal locomotor activity, but confers stress-induced inhibition of the expression of cocaine-induced behavioural sensitization. Stressed mice depleted of dopamine D2 receptors do not manifest long-term depression inhibition. Our results suggest that dopamine D2 receptors have roles in regulating synaptic modification triggered by stress and drug addiction. © 2013 Macmillan Publishers Limited. All rights reserved. | - |
dc.language | English | - |
dc.title | Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours | - |
dc.type | Article | - |
dc.relation.volume | 4 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Nature Communications | - |
dc.identifier.doi | 10.1038/ncomms2598 | - |
dc.identifier.wosid | WOS:000318873900033 | - |
dc.identifier.scopusid | 2-s2.0-84875836000 | - |
dc.author.google | Sim H.-R. | - |
dc.author.google | Choi T.-Y. | - |
dc.author.google | Lee H.J. | - |
dc.author.google | Kang E.Y. | - |
dc.author.google | Yoon S. | - |
dc.author.google | Han P.-L. | - |
dc.author.google | Choi S.-Y. | - |
dc.author.google | Baik J.-H. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |