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Utilization of catalytic hydrolysis of ethyl acetate for solvent removal during microencapsulation

Title
Utilization of catalytic hydrolysis of ethyl acetate for solvent removal during microencapsulation
Authors
Lee M.Kang J.Sah H.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2013
Journal Title
Journal of Microencapsulation
ISSN
0265-2048JCR Link
Citation
vol. 30, no. 4, pp. 346 - 355
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of this study was to apply the specific acid-catalysed hydrolysis of ethyl acetate to completing solvent extraction during an emulsion-based microencapsulation process. The dispersed phase consisting of poly-D,L-lactide-co-glycolide and ethyl acetate was emulsified in an acid catalyst containing aqueous phase. Catalytic hydrolysis of ethyl acetate led to its continual leaching from the dispersed phase of the emulsion, thereby triggering microsphere hardening with high efficiency. Ketoprofen was successfully encapsulated into microspheres via this technique, and liquid chromatography-mass spectrometry showed that its structural integrity was preserved during microencapsulation. Compared to typical solvent extraction approaches, the acid-catalysis technique helped minimize the consumption of a quench liquid. Also, the resultant microspheres displayed excellent dispersibility and decreased propensity for aggregation. Furthermore, the new method provided better drug encapsulation efficiency and lower levels of residual ethyl acetate in microspheres. In conclusion, the acid-catalysis approach had great potential for the preparation of versatile microspheres and nanoparticles. © 2013 Informa UK Ltd.
DOI
10.3109/02652048.2012.735262
Appears in Collections:
약학대학 > 약학과 > Journal papers
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