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Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.

Title
Potential chemopreventive activity of a new macrolide antibiotic from a marine-derived Micromonospora sp.
Authors
Carlson S.Marler L.Nam S.-J.Santarsiero B.D.Pezzuto J.M.Murphy B.T.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2013
Journal Title
Marine Drugs
ISSN
1660-3397JCR Link
Citation
vol. 11, no. 4, pp. 1152 - 1161
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Agents capable of inducing phase II enzymes such as quinone reductase 1 (QR1) are known to have the potential of mediating cancer chemopreventive activity. As part of a program to discover novel phase II enzyme-inducing molecules, we identified a marine-derived actinomycete strain (CNJ-878) that exhibited activity with cultured Hepa 1c1c7 cells. Based on this activity, a new macrolide, juvenimicin C (1), as well as 5-O-α-L-rhamnosyltylactone (2), were isolated from the culture broth of a Micromonospora sp. Compound 1 enhanced QR1 enzyme activity and glutathione levels by two-fold with CD values of 10.1 and 27.7 μM, respectively. In addition, glutathione reductase and glutathione peroxidase activities were elevated. This is the first reported member of the macrolide class of antibiotics found to mediate these responses. © 2013 by the authors; licensee MDPI.
DOI
10.3390/md11041152
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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