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Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

Title
Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva
Authors
Kim S.-H.Kwon S.H.Park S.-H.Lee J.K.Bang H.-S.Nam S.-J.Kwon H.C.Shin J.Oh D.-C.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2013
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 15, no. 8, pp. 1834 - 1837
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells. © 2013 American Chemical Society.
DOI
10.1021/ol4004417
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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